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Mitomycin A

CAT: 0804-HY-130332Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-130332Size:500 µg
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Description
Mitomycin A is a bacterial metabolite. Mitomycin A reduces migration inhibition factor (MIF) production and can be used for the research of cancer[1].
CAS Number
4055-39-4
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Endogenous Metabolite; Macrophage migration inhibitory factor (MIF)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/mitomycin-a.html
Purity
98.3
Solubility
10 mM in DMSO
Smiles
O=C1C(C)=C(OC)C(C2=C1N3[C@@]([C@](N4)([H])[C@]4([H])C3)(OC)[C@@H]2COC(N)=O)=O
Molecular Formula
C16H19N3O6
Molecular Weight
349.34
Precautions
H302, H315, H319, H335
References & Citations
[1]van der Nat JM, et al. Suppression of migration inhibition factor (MIF) production by mitomycins in vitro. Immunobiology. 1986 Aug;172 (1-2) :120-7.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Mitomycin A

Mitomycin A is a member of the family of mitomycins that exhibits antibiotic and antitumour properties as well as a high level of toxicity. It has a role as an alkylating agent, a toxin, an antimicrobial agent and an antineoplastic agent. It is a mitomycin and an ether. It is a conjugate acid of a mitomycin A(1-).

CAS Number4055-39-4
PubChem CID19972
IUPAC Name[(4S,6S,7R,8S)-7,11-dimethoxy-12-methyl-10,13-dioxo-2,5-diazatetracyclo[7.4.0.02,7.04,6]trideca-1(9),11-dien-8-yl]methyl carbamate
Molecular FormulaC16H19N3O6
Molecular Weight349.34
XLogP0.3
Topological Polar Surface Area130
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Heavy Atom Count25
Formal Charge0
Complexity772
SMILES
CC1=C(C(=O)C2=C(C1=O)N3C[C@H]4[C@@H]([C@@]3([C@@H]2COC(=O)N)OC)N4)OC
InChI
InChI=1S/C16H19N3O6/c1-6-11(20)10-9(12(21)13(6)23-2)7(5-25-15(17)22)16(24-3)14-8(18-14)4-19(10)16/h7-8,14,18H,4-5H2,1-3H3,(H2,17,22)/t7-,8+,14+,16-/m1/s1
InChIKey
HYFMSAFINFJTFH-NGSRAFSJSA-N
Chemical Structure
2D Structure
2D structure of Mitomycin A
CAS: 4055-39-4
CID: 19972
Formula: C16H19N3O6
MW: 349.34
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight349.34
XLogP30.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count5
Exact Mass349.12738533
Monoisotopic Mass349.12738533
Topological Polar Surface Area130 Ų
Heavy Atom Count25
Formal Charge0
Complexity772
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
sc-218857EMitomycin A
2713-25Mitomycin C
AR-M02088-01Mitomycin B

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