Trypsin (MS grade)

• Description :

  Trypsin MS grade is a serine protease enzyme, and hydrolyzes proteins at the carboxyl side of the Lysine or Arginine. Trypsin MS grade activates PAR2 and PAR4. Trypsin MS grade induces cell-to-cell membrane fusion in PDCoV infection by the interaction of S glycoprotein of PDCoV and pAPN. Trypsin MS grade also promotes cell proliferation and differentiation. Trypsin MS grade can be used in the research of wound healing and neurogenic inflammation[1][2][3][4][6].

• UNSPSC :

  12352204

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  Protease Activated Receptor (PAR) ; Ser/Thr Protease

• Type :

  Enzyme

• Related Pathways :

  GPCR/G Protein; Metabolic Enzyme/Protease

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Infection; Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/trypsin-ms-grade.html

• Purity :

  95.00

• Solubility :

  10 mM in DMSO

• Smiles :

  [Trypsin(MSgrade)]

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]Bhupendra S.Kaphalia. Chapter 16 - Biomarkers of acute and chronic pancreatitis. Biomarkers in Toxicology. 2014, Pages 279-289.|[2]Yue-Lin Yang, et al. Trypsin promotes porcine deltacoronavirus mediating cell-to-cell fusion in a cell type-dependent manner. Emerg Microbes Infect. 2020 Feb 24;9 (1) :457-468.|[3]H Amano, et al. Trypsin promotes C6 glioma cell proliferation in serum- and growth factor-free medium. Neurosci Res. 1996 Jul;25 (3) :203-8.|[4]Michael J. V. White, et al. Trypsin Potentiates Human Fibrocyte Differentiation. PLoS One. 2013; 8 (8) : e70795.|[5]R Costa, et al. Evidence for the role of neurogenic inflammation components in trypsin-elicited scratching behaviour in mice. Br J Pharmacol. 2008 Jul;154 (5) :1094-103.|[6]F Schmidlin, et al. Protease-activated receptors: how proteases signal to cells. Curr Opin Pharmacol. 2001 Dec;1 (6) :575-82.|[7]Bhupendra S.Kaphalia, et al. Chapter 16 - Biomarkers of acute and chronic pancreatitis. Biomarkers in Toxicology. 2014, Pages 279-289.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  Store at -20°C for 2 years

• Scientific Category :

  Enzyme

• Clinical Information :

  No Development Reported

• Isoform :

  PAR2; PAR4

• CAS Number :

  [9002-07-7]