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EC0488

CAT: 0804-HY-128939Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-128939Size:1 Each
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Description
EC0488 is used to synthesize EC0531 with folate receptor (FR) -specific and anti-tumor activities[1].
CAS Number
1059477-92-7
UNSPSC
12352005
Target
Antifolate
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ec0488.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=NC(CNC3=CC=C(C(N[C@H](C(O)=O)CCC(N[C@@H](CCC(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)=O)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCC(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)=O)C(N[C@@H](CS)C(O)=O)=O)=O)=O)=O)=O)=O)=O)C=C3)=CNC2=NC(N)=N1
Molecular Formula
C65H98N16O34S
Molecular Weight
1679.63
References & Citations
[1]Leamon CP, et al. Enhancing the therapeutic range of a targeted small-molecule tubulysin conjugate for folate receptor-based cancer therapy. Cancer Chemother Pharmacol. 2017 Jun;79 (6) :1151-1160.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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