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Arborinine

CAT: 0804-HY-128912-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-128912-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Arborinine is a potent and orally activeLSD1 inhibitor. Arborinine increases the expression of H3K4me1/2, H3K9me1/2, E-cad protein and decreases the expression of UBE2O protein level. Arborinine induces cell cycle arrest at S phase. Arborinine shows antitumor activity [1][2].
CAS Number
5489-57-6
UNSPSC
12352005
Target
Histone Demethylase
Type
Natural Products
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/arborinine.html
Purity
99.87
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
O=C1C2=C(C=CC=C2)N(C)C3=CC(OC)=C(OC)C(O)=C13
Molecular Formula
C16H15NO4
Molecular Weight
285.29
References & Citations
[1]Feng C, et al. Arborinine from Glycosmis parva leaf extract inhibits clear-cell renal cell carcinoma by inhibiting KDM1A/UBE2O signaling. Food Nutr Res. 2022 Sep 16;66.|[2]Chu Y, et al. Arborinine, a potential LSD1 inhibitor, inhibits epithelial-mesenchymal transition of SGC-7901 cells and adriamycin-resistant gastric cancer SGC-7901/ADR cells. Invest New Drugs. 2021 Jun;39 (3) :627-635.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
KDM1/LSD1

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