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AM12

CAT: 0804-HY-128561Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-128561Size:1 Each
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Description
AM12 inhibits Lanthanide-evoked TRPC5 activity with an IC50 of 0.28 μM[1].
CAS Number
2387510-84-9
UNSPSC
12352005
Target
TRP Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/am12.html
Solubility
10 mM in DMSO
Smiles
O=C1C(O)=C(C2=CC=CC=C2Br)OC3=C1C(O)=CC(O)=C3
Molecular Formula
C15H9BrO5
Molecular Weight
349.13
References & Citations
[1]Naylor J, et al. Natural and synthetic flavonoid modulation of TRPC5 channels. Br J Pharmacol. 2016 Feb;173 (3) :562-74.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

2-(2-bromophenyl)-3,5,7-trihydroxy-4H-chromen-4-one
CAS Number2387510-84-9
PubChem CID137553166
IUPAC Name2-(2-bromophenyl)-3,5,7-trihydroxychromen-4-one
Molecular FormulaC15H9BrO5
Molecular Weight349.13
XLogP2.9
Topological Polar Surface Area87
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Heavy Atom Count21
Formal Charge0
Complexity463
SMILES
C1=CC=C(C(=C1)C2=C(C(=O)C3=C(C=C(C=C3O2)O)O)O)Br
InChI
InChI=1S/C15H9BrO5/c16-9-4-2-1-3-8(9)15-14(20)13(19)12-10(18)5-7(17)6-11(12)21-15/h1-6,17-18,20H
InChIKey
OVIAJBSVWWYJSD-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2-(2-bromophenyl)-3,5,7-trihydroxy-4H-chromen-4-one
CAS: 2387510-84-9
CID: 137553166
Formula: C15H9BrO5
MW: 349.13
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight349.13
XLogP32.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count1
Exact Mass347.96334
Monoisotopic Mass347.96334
Topological Polar Surface Area87 Ų
Heavy Atom Count21
Formal Charge0
Complexity463
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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