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Alimemazine

CAT: 0804-HY-12752Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-12752Size:1 Each
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Description
Alimemazine is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA) -receptor antagonist.Alimemazine (Trimeprazine) is also acts as a partial agonist against the histamine H1 receptor (H1R) and other GPCRs. Alimemazine displays antiserotonin, antispasmodic, and antiemetic properties[1][2].
CAS Number
84-96-8
Product Name Alternative
Trimeprazine
UNSPSC
12352005
Hazard Statement
H301-H317-H318-H411
Target
Histamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/alimemazine.html
Solubility
10 mM in DMSO
Smiles
CC(CN(C)C)CN1C2=CC=CC=C2SC3=CC=CC=C31
Molecular Formula
C18H22N2S
Molecular Weight
298.45
Precautions
P261-P264-P270-P272-P273-P280-P302+P352-P305+P351+P338-P330-P362+P364-P391-P405-P501
References & Citations
[1]Singh B, et al. Bioanalytical method development and validation of alimemazine in human plasma by LC-MS/MS and its application in bioequivalence studies. J Pharm Bioallied Sci. 2013 Oct;5 (4) :257-64.|[2]Kuznetsova A, et al. Trimeprazine increases IRS2 in human islets and promotes pancreatic β cell growth and function in mice. JCI Insight. 2016;1 (3) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
H1 Receptor

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