Territrem B

• Description :

  Territrem B is an irreversible inhibitor of Acetylcholinesterase (AChE) inhibitor. Territrem B is also a fungal meroterpenoid that can be isolated from Aspergillus terreus[1][2].

• UNSPSC :

  12352005

• Hazard Statement :

  H301+H311, H330

• Target :

  Cholinesterase (ChE)

• Type :

  Natural Products

• Related Pathways :

  Neuronal Signaling

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection; Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/territrem-b.html

• Purity :

  95.0

• Solubility :

  10 mM in DMSO

• Smiles :

  O[C@@]12[C@@]3([C@@](CC[C@]1(OC4=C(C(OC(C5=CC(OC)=C(C(OC)=C5)OC)=C4)=O)C2)C)(C(C)(C=CC3=O)C)O)C

• Molecular Formula :

  C29H34O9

• Molecular Weight :

  526.57

• Precautions :

  H301+H311, H330

• References & Citations :

  [1]Chen JW, et al. Territrem B, a tremorgenic mycotoxin that inhibits acetylcholinesterase with a noncovalent yet irreversible binding mechanism. J Biol Chem. 1999 Dec 3;274 (49) :34916-23. |[2]Cheung J, et al. Acetylcholinesterase complexes with the natural product inhibitors dihydrotanshinone I and territrem B: binding site assignment from inhibitor competition and validation through crystal structure determination. J Mol Neurosci. 2014 Jul;53 (3) :506-10.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C (Powder, protect from light, stored under nitrogen)

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported

• Isoform :

  AChE

• CAS Number :

  [70407-20-4]