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Apoptolidin

CAT: 0804-HY-126679Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-126679Size:100 µg
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Description
Apoptolidin is a polyketide isolated from Nocardiopsis bacteria[1]. Apoptolidin is a selective mitochondrial F1FO ATPase inhibitor. Apoptolidin is an apoptosis inducer and induces apoptotic cell death in cells transformed with the adenovirus type 12 oncogenes including ElA (IC50=10-17 ng/ml) but not in normal cells[1][2].
CAS Number
194874-06-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; ATP Synthase
Type
Natural Products
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/apoptolidin.html
Purity
95.60
Solubility
DMSO : 1 mg/mL (ultrasonic; warming)
Smiles
O[C@H]([C@](OC(/C(C)=C/C(C)=C/C(C)=C/[C@H]1C)=O)([H])C[C@@H]([C@H](CC/C=C(/C=C/[C@H]1O[C@H](O[C@H]2C)[C@H]([C@@H]([C@H]2OC)O)O)C)O)OC)[C@](O[C@@H]([C@@H]3C)C[C@H](COC)O[C@H](O[C@H]4C)C[C@](O)([C@H]4O[C@H](O[C@@H]5C)C[C@H]([C@@H]5O)OC)C)([C@@H]([C@H]3O)C)O
Molecular Formula
C58H96O21
Molecular Weight
1129.37
Precautions
H302, H315, H319, H335
References & Citations
[1]J W Kim, et al. Apoptolidin, a new apoptosis inducer in transformed cells from Nocardiopsis sp. J Antibiot (Tokyo) . 1997 Jul;50 (7) :628-30.|[2]A R Salomon, et al. Understanding and exploiting the mechanistic basis for selectivity of polyketide inhibitors of F (0) F (1) -ATPase. Proc Natl Acad Sci U S A. 2000 Dec 19;97 (26) :14766-71.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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