DMEA-PNU-159682 (dichloroacetate)

DMEA-PNU-159682 (dichloroacetate)

• CAS Number: 1799421-49-0
• UNSPSC Description: DMEA-PNU-159682 (molecule D12) dichloroacetate is an ADC cytotoxin molecule including metabolites of nemorubicin (MMDX) from liver microsomes and a potent ADCs cytotoxin PNU-159682[1][2].
• Target Antigen: ADC Cytotoxin
• Type: Reference compound
• Related Pathways: Antibody-drug Conjugate/ADC Related
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/dmea-pnu-159682-dichloroacetate.html
• Solubility: 10 mM in DMSO
• Smiles: OC(C(Cl)Cl)=O.C[C@H]1[C@]2([H])[C@](N3[C@]([C@H](OCC3)OC)([H])O2)([H])C[C@](O1)([H])O[C@@H]4C5=C(C[C@](C(COC(N(C)CCNC)=O)=O)(O)C4)C(O)=C6C(C(C7=C(OC)C=CC=C7C6=O)=O)=C5O.OC(C(Cl)Cl)=O
• Molecular Weight: 1013.65
• References & Citations: [1]Chen Jingkang, et al. Disubstituted maleic amide class connexon for antibody-drug conjugate and its preparation method and application. CN108101825A.|[2]John Flygare, et al. Anthracycline disulfide intermediates, antibody-drug conjugates and methods. WO2016040825A1
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported