Products for Research Use Only
RegisterLogin

SAICAR-d3

CAT: 0804-HY-126585SSize: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-126585SSize:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
SAICAR-d3 is the deuterium labeled SAICAR. SAICAR is an intermediate of de novo purine nucleotide biosynthesis, activates pyruvate kinase isoform M2 (PKM2) in an isozyme-selective manner, with an EC50 of 0.3 mM. SAICAR stimulates PKM2 and promotes cancer cell survival in glucose-limited conditions[1][2].
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Purity
96.57
Solubility
10 mM in DMSO
Smiles
O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N2C(N)=C(C(N[C@@](C(O)=O)([2H])C([2H])([2H])C(O)=O)=O)N=C2
Molecular Formula
C13H16D3N4O12P
Molecular Weight
457.30
References & Citations
[1]Keller KE, et al. SAICAR stimulates pyruvate kinase isoform M2 and promotes cancer cell survival in glucose-limited conditions. Science. 2012 Nov 23;338 (6110) :1069-72. |[2]Keller KE, et al. SAICAR induces protein kinase activity of PKM2 that is necessary for sustained proliferative signaling of cancer cells. Mol Cell. 2014 Mar 6;53 (5) :700-9. |[3]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-223.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, protect from light)
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

Related Products

CatalogName
HY-126585-01SAICAR
HY-15398S3-01Vitamin D3-d3
HY-132348S1Granisetron-d3 (1-methyl-d3)
HY-150954SL-Methionine-d3 (S-methyl-d3) Methyl-d3-sulfonium Chloride
HY-W758392(±) -Ipratropium-d3 Bromide (N-methyl-d3)
HY-B1213AS-01Trimipramine-d3 (N-methyl-d3) (maleate)
HY-17373S2Posaconazole-d3
HY-15345ASTetrahydrouridine-d3
HY-14771SImeglimin-d3
HY-14283S1-01Luliconazole-d3

Alternative Products

CatalogName
GTR19203132SAICAR
A5050-01Azithromycin-d3 (CP-62993-d3, XZ-450-d3, Azitrocin-d3, Ribotrex-d3, Sumamed-d3, Trozocina-d3, Zithromaz-d3, Zitromax-d3)
TRC-V676233-1MGVitamin D3-d3
RM-V307743-01Vitamin D3-[D3]
CS-O-40039Thiamphenicol-d3 (methyl-d3)
CS-O-59395Ritlecitinib-d3 (Acrylic-d3)
CS-T-94959Methazolamide-d3 (Acetyl-D3)
CS-SN-00009Cabotegravir-d3 (Phenyl-d3)
TMIJ-0466-01Acephate-d3 (acetyl-d3)
TMIJ-0240-01Lacosamide-d3 (Acetyl-d3)

Popular Products