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NCL1

CAT: 0804-HY-12645Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-12645Size:1 Each
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Description
NCL1 is a phenylcyclopropylamine (PCPA) -based Lysine-specific demethylase 1 (LSD1) inhibitor. NCL1 selectively inhibits LSD1 in preference to LSD2, with IC50 values of 2.5 and 26 μM for LSD1 and LSD2, respectively[1].
CAS Number
1196119-03-5
UNSPSC
12352005
Target
Histone Demethylase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ncl1.html
Solubility
10 mM in DMSO
Smiles
O=C(N[C@H](C(NCC1=CC=CC=C1)=O)CCOC2=CC=CC(C3C(N)C3)=C2)C4=CC=CC=C4
Molecular Formula
C27H29N3O3
Molecular Weight
443.54
References & Citations
[1]Kakizawa T, et al. Evaluation of phenylcyclopropylamine compounds by enzymatic assay of lysine-specific demethylase 2 in the presence of NPAC peptide. Bioorg Med Chem Lett. 2016 Feb 15;26 (4) :1193-5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
KDM1/LSD1

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