2-Methylthio-AMP (diTEA)

CAT: 0804-HY-125989BSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-125989BSize:1 Each
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Description
2-Methylthio-AMP (2-MeSAMP) diTEA is a selective and direct P2Y12 antagonist. 2-Methylthio-AMP diTEA is an inhibitor of ADP-dependent platelet aggregation[1][2][3].
CAS Number
[1227193-98-7]
Product Name Alternative
2-MeSAMP (diTEA) ; 2-Methylthioadenosine 5′-monophosphate (diTEA) ; 2-Methylthioadenosine 5′-phosphate (diTEA)
UNSPSC
12352005
Target
P2Y Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/2-methylthio-amp-ditea.html
Purity
98.0
Solubility
10 mM in DMSO
Smiles
O[C@H]1[C@@H](O)[C@H](N2C3=NC(SC)=NC(N)=C3N=C2)O[C@@H]1COP(O)(O)=O.CCN(CC)CC.CCN(CC)CC
Molecular Formula
C23H46N7O7PS
Molecular Weight
595.69
References & Citations
[1]John H Cleator, et al. Racial differences in resistance to P2Y12 receptor antagonists in type 2 diabetic subjects. J Pharmacol Exp Ther. 2014 Oct;351 (1) :33-43.|[2]Bernhard H Rauch, et al. Regulation of functionally active P2Y12 ADP receptors by thrombin in human smooth muscle cells and the presence of P2Y12 in carotid artery lesions. Arterioscler Thromb Vasc Biol. 2010 Dec;30 (12) :2434-42.|[3]A Malinin, et al. Validation of a VerifyNow-P2Y12 cartridge for monitoring platelet inhibition with clopidogrel. Methods Find Exp Clin Pharmacol. 2006 Jun;28 (5) :315-22.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2Y12 Receptor

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