2-Methylthio-AMP (diTEA)

2-Methylthio-AMP (diTEA)

• CAS Number: 1227193-98-7
• UNSPSC Description: 2-Methylthio-AMP (2-MeSAMP) diTEA is a selective and direct P2Y12 antagonist. 2-Methylthio-AMP diTEA is an inhibitor of ADP-dependent platelet aggregation[1][2][3].
• Target Antigen: P2Y Receptor
• Type: Reference compound
• Related Pathways: GPCR/G Protein
• Applications: Neuroscience-Neuromodulation
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/2-methylthio-amp-ditea.html
• Purity: 98.0
• Solubility: 10 mM in DMSO
• Smiles: O[C@H]1[C@@H](O)[C@H](N2C3=NC(SC)=NC(N)=C3N=C2)O[C@@H]1COP(O)(O)=O.CCN(CC)CC.CCN(CC)CC
• Molecular Weight: 595.69
• References & Citations: [1]John H Cleator, et al. Racial differences in resistance to P2Y12 receptor antagonists in type 2 diabetic subjects. J Pharmacol Exp Ther. 2014 Oct;351(1):33-43.|[2]Bernhard H Rauch, et al. Regulation of functionally active P2Y12 ADP receptors by thrombin in human smooth muscle cells and the presence of P2Y12 in carotid artery lesions. Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2434-42.|[3]A Malinin, et al. Validation of a VerifyNow-P2Y12 cartridge for monitoring platelet inhibition with clopidogrel. Methods Find Exp Clin Pharmacol. 2006 Jun;28(5):315-22.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported