Actinomycin X2

CAT: 0804-HY-125747Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-125747Size:1 mg
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Description
Actinomycin X2 (Actinomycin V), produced by many Streptomyces sp., shows strong inhibition of MRSA with a minimum inhibitory concentration (MIC) value of 0.25 μg/mL. Actinomycin X2 can be used for cancer and bacterial infection[1][2].
CAS Number
[18865-48-0]
Product Name Alternative
Actinomycin V
UNSPSC
12352209
Hazard Statement
H300, H310, H330, H361
Target
Antibiotic; Apoptosis; Bacterial
Type
Peptides
Related Pathways
Anti-infection; Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/actinomycin-x2.html
Purity
98.00
Solubility
DMSO : 12.7 mg/mL (ultrasonic; warming)
Smiles
O=C(N[C@H](C(N[C@H](C(C)C)C(N([C@@]([H])(C1)C2=O)CC1=O)=O)=O)[C@@H](C)OC([C@H](C(C)C)N(C)C(CN2C)=O)=O)C(C3=NC4=C(C(N[C@H](C(N[C@H](C(C)C)C(N5[C@@]([H])(CCC5)C6=O)=O)=O)[C@@H](C)OC([C@H](C(C)C)N(C)C(CN6C)=O)=O)=O)C=CC(C)=C4OC3=C7C)=C(N)C7=O
Molecular Formula
C62H84N12O17
Molecular Weight
1269.40
Precautions
H300, H310, H330, H361
References & Citations
[1]Zhiyu Chen, et al. Anti-MRSA Activity of Actinomycin X 2 and Collismycin A Produced by Streptomyces globisporusWA5-2-37 From the Intestinal Tract of American Cockroach (Periplaneta americana) . Front Microbiol. 2020 Apr 7;11:555.|[2]Liu J, et al. Apoptosis of human prostate cancer cells induced by marine actinomycin X2 through the mTOR pathway compounded by MiRNA144. Anticancer Drugs. 2016 Mar;27 (3) :156-63.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

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