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Antileukinate

CAT: 0804-HY-125567Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-125567Size:500 µg
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Description
Antileukinate, a hexapeptide, is a potent inhibitor of CXC-chemokine receptor (CXCR) . Antileukinate inhibits neutrophil chemotaxis and activation. Antileukinate can be used for the research of acute inflammation and injury[1][2][3].
CAS Number
138559-60-1
UNSPSC
12352209
Target
CXCR
Type
Peptides
Related Pathways
GPCR/G Protein; Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/antileukinate.html
Solubility
10 mM in DMSO
Smiles
CC(N[C@@H](CCCNC(N)=N)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CS)C(N[C@H](C(N)=O)CCCNC(N)=N)=O)=O)CC1=CNC2=C1C=CC=C2)=O)CC3=CNC4=C3C=CC=C4)=O)CCCNC(N)=N)=O)=O
Molecular Formula
C45H66N18O7S
Molecular Weight
1003.19
References & Citations
[1]Madhav Bhatia, et al. Treatment with antileukinate, a CXCR2 chemokine receptor antagonist, protects mice against acute pancreatitis and associated lung injury. Regul Pept. 2007 Jan 10;138 (1) :40-8.|[2]Yuji Fukuno, et al. Chemokine receptor inhibitor, Antileukinate, suppressed ovalbumin-induced eosinophilic inflammation in the airway. Cytokine. 2003 Jun 7;22 (5) :116-25.|[3]S HayashiY, et al. Antileukinate, a hexapeptide inhibitor of CXC-chemokine receptor, suppresses bleomycin-induced acute lung injury in mice. Lung. 2002;180 (6) :339-48.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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