BRD1991

CAT: 0804-HY-125191Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-125191Size:1 Each

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Description

BRD1991 selectively disrupts Beclin 1/Bcl-2 binding and induces autophagy without triggering apoptosis or other forms of cell death[1].

CAS Number

2235468-02-5

UNSPSC

12352005

Target

Bcl-2 Family; Beclin1

Type

Reference compound

Related Pathways

Apoptosis; Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/brd1991.html

Solubility

10 mM in DMSO

Smiles

CN1C2=CC=CC=C2C3=C1C(N(C(CO)C)CC(C)C(CN(C(C4=CC(Cl)=CC(Cl)=C4)=O)C)OCC5=CC=CC=C53)=O

Molecular Formula

C33H35Cl2N3O4

Molecular Weight

608.55

References & Citations

[1]Wei-Chung Chiang, et al. High-Throughput Screens To Identify Autophagy Inducers That Function by Disrupting Beclin 1/Bcl-2 Binding. ACS Chem Biol. 2018 Aug 17;13 (8) :2247-2260.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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