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SR12343

CAT: 0804-HY-123936-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-123936-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SR12343, an IKK/NF-κB inhibitor, is a NF-κB essential modulator (NEMO) -binding domain (NBD) mimetic. SR12343 inhibits TNF-α- and LPS-induced NF-κB activation by blocking the interaction between IKKβ and NEMO, with an IC50 of 37.02 μM for TNF-α-mediated NF-κB activation. SR12343 suppresses LPS-induced acute pulmonary inflammation in mice. SR12343 can be used for research of inflammatory and degenerative diseases[1].
CAS Number
2055101-86-3
UNSPSC
12352005
Target
IKK; NF-κB
Type
Reference compound
Related Pathways
NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sr12343.html
Purity
99.66
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(NCCC1=CC=CC(Br)=C1)CNC2=NC=C(Cl)C=C2
Molecular Formula
C15H15BrClN3O
Molecular Weight
368.66
References & Citations
[1]Zhao J, et al. Development of novel NEMO-binding domain mimetics for inhibiting IKK/NF-κB activation. PLoS Biol. 2018 Jun 11;16 (6) :e2004663. |[2]Benhamú B, et al. New Trends in Aging Drug Discovery. Biomedicines. 2022 Aug 18;10 (8) :2006.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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