Methyl gerfelin

• Description:

  Methyl gerfelin inhibits osteoclast differentiation by binding 3 major cellular proteins: glyoxalase 1 (GLO1), sterol binding protein 2 (SCP2), and small glutamine-rich tetratricopeptide repeat containing protein A (SGTA) . Methyl gerfelin is a potent GLO1 inhibitor related to the flavonoid class[1][2].

• UNSPSC:

  12352005

• Target:

  Glyoxalase (GLO)

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/methyl-gerfelin.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(OC)C1=C(C)C=C(OC2=CC(C)=CC(O)=C2O)C=C1O

• Molecular Formula:

  C16H16O6

• Molecular Weight:

  304.29

• References & Citations:

  [1]Kanoh N, et al. Dual structure-activity relationship of osteoclastogenesis inhibitor methyl gerfelin based on TEG scanning. Bioconjug Chem. 2013 Jan 16;24 (1) :44-52. |[2]Perez C, et al. Metal-Binding Pharmacophore Library Yields the Discovery of a Glyoxalase 1 Inhibitor. J Med Chem. 2019 Feb 14;62 (3) :1609-1625.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [700870-56-0]