JI130

CAT: 0804-HY-124484Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-124484Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

JI130 (JI051 derivative) is a stabilizer for the Hes1-PHB2 interaction. JI130 inhibits the ability of Hes1 to repress transcription. JI130 significantly reduces the tumor growth in a murine pancreatic tumor model and has the potential for managing pancreatic cancer[1].

CAS Number

2234271-86-2

UNSPSC

12352005

Target

Notch

Type

Reference compound

Related Pathways

Neuronal Signaling; Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ji130.html

Purity

99.41

Solubility

DMSO : 2 mg/mL (ultrasonic; warming)

Smiles

O=C(/C=C/C1=CNC2=C1C=CC=C2OC)NCCC3=CC=CC=C3OCC=C

Molecular Formula

C23H24N2O3

Molecular Weight

376.45

References & Citations

[1]Amelie Perron, et al. Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone. J Biol Chem. 2018 May 25;293 (21) :8285-8294.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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