Products for Research Use Only
RegisterLogin

RO6889678

CAT: 0804-HY-124364Size: 2 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-124364Size:2 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
RO6889678 is a highly potent HBV capsid formation inhibitor with a complex absorption, distribution, metabolism, and excretion (ADME) profile. RO6889678 is a potent inducer of CYP3A4 and coregulated proteins in human hepatocytes. RO6889678 is metabolized by a combination of CYP3A4-mediated oxidation and UDP-glucuronosyltransferase UGT1A3- and UGT1A1-mediated direct glucuronidation[1].
CAS Number
1578153-27-1
UNSPSC
12352005
Target
Cytochrome P450; HBV
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Infection; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ro6889678.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H]1N(CC2=C(C(OC)=O)[C@H](C3=CC=C(F)C=C3Cl)N=C(C4=NC=CS4)N2)CCOC1)O
Molecular Formula
C21H20ClFN4O5S
Molecular Weight
494.92
References & Citations
[1]Nicole A Kratochwil, et al. Simultaneous Assessment of Clearance, Metabolism, Induction, and Drug-Drug Interaction Potential Using a Long-Term In Vitro Liver Model for a Novel Hepatitis B Virus Inhibitor. J Pharmacol Exp Ther. 2018 May;365 (2) :237-248.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
CYP3

Alternative Products

CatalogName
MBS3847007-01RO6889678
A22490-50RO6889678 50mg
A22490-25RO6889678 25mg
A22490-1RO6889678 1mg
A22490-100RO6889678 100mg
A22490-10RO6889678 10mg
A22490-5RO6889678 5mg
A22490-2RO6889678 2mg
A22490-10mM-DRO6889678 10mM * 1mL in DMSO

Popular Products