VE-465

• Description :

  VE-465 is an Aurora kinase inhibitor. VE-465 induces cancer cell apoptosis. VE-465 has anticancer effects in multiple tumor models[1][2].

• UNSPSC :

  12352005

• Target :

  Aurora Kinase

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Epigenetics

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ve-465.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CCC(NC1=CC=C(C=C1)SC2=NC(NC3=NNC(C)=C3)=CC(N4CCN(CC4)C)=N2)=O

• Molecular Formula :

  C22H28N8OS

• Molecular Weight :

  452.58

• References & Citations :

  [1]Lin ZZ, et al. The Aurora kinase inhibitor VE-465 has anticancer effects in pre-clinical studies of human hepatocellular carcinoma. J Hepatol. 2009 Mar;50 (3) :518-27.|[2]Evans R, et al. Aurora A kinase RNAi and small molecule inhibition of Aurora kinases with VE-465 induce apoptotic death in multiple myeloma cells. Leuk Lymphoma. 2008 Mar;49 (3) :559-69.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [639089-73-9]