VE-465

• Description:

  VE-465 is an Aurora kinase inhibitor. VE-465 induces cancer cell apoptosis. VE-465 has anticancer effects in multiple tumor models[1][2].

• UNSPSC:

  12352005

• Target:

  Aurora Kinase

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Epigenetics

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ve-465.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CCC(NC1=CC=C(C=C1)SC2=NC(NC3=NNC(C)=C3)=CC(N4CCN(CC4)C)=N2)=O

• Molecular Formula:

  C22H28N8OS

• Molecular Weight:

  452.58

• References & Citations:

  [1]Lin ZZ, et al. The Aurora kinase inhibitor VE-465 has anticancer effects in pre-clinical studies of human hepatocellular carcinoma. J Hepatol. 2009 Mar;50 (3) :518-27.|[2]Evans R, et al. Aurora A kinase RNAi and small molecule inhibition of Aurora kinases with VE-465 induce apoptotic death in multiple myeloma cells. Leuk Lymphoma. 2008 Mar;49 (3) :559-69.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [639089-73-9]