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Kentsin

CAT: 0804-HY-123492Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-123492Size:1 Each
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Description
Kentsin (Thr-Pro-Arg-Lys), a contraceptive tetrapeptide, is originally extracted from hamster embryos. Kentsin prevents the maturation of Graafian follicles and consequently inhibits ovulation, without binding to opioid receptors. Kentsin has opiate properties on gastrointestinal motility[1][3][5][6].
CAS Number
56767-30-7
UNSPSC
12352209
Target
Opioid Receptor
Type
Peptides
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/kentsin.html
Solubility
10 mM in DMSO
Smiles
NCCCC[C@H](NC([C@@H](NC([C@H]1N(CCC1)C([C@@H](N)[C@@H](C)O)=O)=O)CCCNC(N)=N)=O)C(O)=O
Molecular Formula
C21H40N8O6
Molecular Weight
500.59
References & Citations
[1]Fox DA, et al. Kentsin: tetrapeptide from hamster embryos produces naloxone-sensitive effects without binding to opioid receptors. Peptides. 1987 Jul-Aug;8 (4) :613-8. |[2]Suk WA, et al. Increased expression of endogenous xenotropic murine retrovirus by treatment with the tetrapeptides, tuftsin and kentsin. J Gen Virol. 1981 Jan;52 (Pt 1) :189-94. |[3]Bueno L, et al. Central opioid-like influence of a tetrapeptide from hamster embryo (kentsin) on gastrointestinal motility in dogs. Eur J Pharmacol. 1985 Aug 7;114 (1) :67-70. |[4]Buéno L, et al. A tetrapeptide isolated from hamster embryo with central opiate properties on gastrointestinal motility but not on pain perception. Life Sci. 1986 Jul 14;39 (2) :141-6. |[5]Wieczorek Z, et al. The immunomodulatory activity of tetra- and tripeptides of tuftsin-kentsin group. Peptides. 1994;15 (2) :215-21.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported

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