Kentsin

• Description:

  Kentsin (Thr-Pro-Arg-Lys), a contraceptive tetrapeptide, is originally extracted from hamster embryos. Kentsin prevents the maturation of Graafian follicles and consequently inhibits ovulation, without binding to opioid receptors. Kentsin has opiate properties on gastrointestinal motility[1][3][5][6].

• UNSPSC:

  12352209

• Target:

  Opioid Receptor

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Endocrinology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/kentsin.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NCCCC[C@H] (NC ([C@@H] (NC ([C@H]1N (CCC1) C ([C@@H] (N) [C@@H] (C) O) =O) =O) CCCNC (N) =N) =O) C (O) =O

• Molecular Formula:

  C21H40N8O6

• Molecular Weight:

  500.59

• References & Citations:

  [1]Fox DA, et al. Kentsin: tetrapeptide from hamster embryos produces naloxone-sensitive effects without binding to opioid receptors. Peptides. 1987 Jul-Aug;8 (4) :613-8. |[2]Suk WA, et al. Increased expression of endogenous xenotropic murine retrovirus by treatment with the tetrapeptides, tuftsin and kentsin. J Gen Virol. 1981 Jan;52 (Pt 1) :189-94. |[3]Bueno L, et al. Central opioid-like influence of a tetrapeptide from hamster embryo (kentsin) on gastrointestinal motility in dogs. Eur J Pharmacol. 1985 Aug 7;114 (1) :67-70. |[4]Buéno L, et al. A tetrapeptide isolated from hamster embryo with central opiate properties on gastrointestinal motility but not on pain perception. Life Sci. 1986 Jul 14;39 (2) :141-6. |[5]Wieczorek Z, et al. The immunomodulatory activity of tetra- and tripeptides of tuftsin-kentsin group. Peptides. 1994;15 (2) :215-21.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• CAS Number:

  56767-30-7