DDRI-18

• Description:

  DDRI-18 is a DNA damage response inhibitor that inhibits the non-homologous end-joining (NHEJ) DNA repair process. DDRI-18 is an effective chemosensitizing agent[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H315-H319-H335-H413

• Target:

  DNA/RNA Synthesis

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ddri-18.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NC1=CC=CC (C2=NC3=CC=C (C=C3N2) C4=CC=C5N=C (NC5=C4) C6=CC (N) =CC=C6) =C1

• Molecular Formula:

  C26H20N6

• Molecular Weight:

  416.48

• Precautions:

  P261-P264-P271-P273-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

• References & Citations:

  [1]D W Jun, et al. Characterization of DDRI-18 (3,3'- (1H,3'H-5,5'-bibenzo[d]imidazole-2,2'-diyl) dianiline), a novel small molecule inhibitor modulating the DNA damage response. Br J Pharmacol. 2012 Sep;167 (1) :141-50.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  4402-18-0