DDRI-18

• UNSPSC Description:

  DDRI-18 is a DNA damage response inhibitor that inhibits the non-homologous end-joining (NHEJ) DNA repair process. DDRI-18 is an effective chemosensitizing agent[1].

• Target Antigen:

  DNA/RNA Synthesis

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ddri-18.html

• Solubility:

  10 mM in DMSO

• Smiles:

  NC1=CC=CC(C2=NC3=CC=C(C=C3N2)C4=CC=C5N=C(NC5=C4)C6=CC(N)=CC=C6)=C1

• Molecular Weight:

  416.48

• References & Citations:

  [1]D W Jun, et al. Characterization of DDRI-18 (3,3'-(1H,3'H-5,5'-bibenzo[d]imidazole-2,2'-diyl)dianiline), a novel small molecule inhibitor modulating the DNA damage response. Br J Pharmacol. 2012 Sep;167(1):141-50.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  4402-18-0