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DB07107

CAT: 0804-HY-123390Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-123390Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DB07107 is a potent agent resistant T315I mutant Bcr-Abl tyrosine kinase inhibitor. DB07107 is also a potent Akt1 inhibitor with an IC50 value of 360 nM[1][2].
CAS Number
552332-71-5
UNSPSC
12352005
Target
Akt; Bcr-Abl
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/db07107.html
Solubility
10 mM in DMSO
Smiles
N[C@@H](COC1=CN=CC(/C=C/C2=CC=NC=C2)=C1)CC3=CNC4=C3C=CC=C4
Molecular Formula
C23H22N4O
Molecular Weight
370.45
References & Citations
[1]Banavath HN, et al. Identification of novel tyrosine kinase inhibitors for drug resistant T315I mutant BCR-ABL: a virtual screening and molecular dynamics simulations study. Sci Rep. 2014 Nov 10;4:6948.|[2]Li Q, et al. Discovery of trans-3,4'-bispyridinylethylenes as potent and novel inhibitors of protein kinase B (PKB/Akt) for the treatment of cancer: Synthesis and biological evaluation. Bioorg Med Chem Lett. 2006 Mar 15;16 (6) :1679-85.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Akt1

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