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Chrysotoxine

CAT: 0804-HY-123298Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-123298Size:1 mg
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Description
Chrysotoxine is a dual inhibitor of Src/Akt. Chrysotoxine suppresses cancer stem cells (CSCs) phenotypes by down-regulating Src/Akt signaling. Chrysotoxine reduces cell viability and increases apoptosis level in H460 and H23 cells instead of non-tumor cell lines. Chrysotoxine shows rapid excretion and low bioavailability in rats. Chrysotoxine is used in cancer research[1][2].
CAS Number
156951-82-5
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Akt; Apoptosis; Src
Type
Natural Products
Related Pathways
Apoptosis; PI3K/Akt/mTOR; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/chrysotoxine.html
Purity
99.52
Solubility
DMSO : 6.37 mg/mL (ultrasonic; warming)
Smiles
OC1=C(C=C(C=C1OC)CCC2=CC=C(C(OC)=C2)OC)OC
Molecular Formula
C18H22O5
Molecular Weight
318.36
Precautions
H315, H319
References & Citations
[1]Bhummaphan N, et al. Cancer Stem Cell-Suppressing Activity of Chrysotoxine, a Bibenzyl from Dendrobium pulchellum. J Pharmacol Exp Ther. 2018 Feb;364 (2) :332-346.|[2]Fan J, et al. Determination of chrysotoxine in rat plasma by liquid chromatography-tandem mass spectrometry and its application to a rat pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Sep 15;967:57-62.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported

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