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Mefruside

CAT: 0804-HY-123179Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-123179Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mefruside is an orally active diuretic and a carbonic anhydrase inhibitor, with a mild hypotensive effect. Mefruside inhibits the synthesis of urea in an isolated rat liver perfusion model. Mefruside can be used in studies of oedema and hypertension[1][2].
CAS Number
7195-27-9
UNSPSC
12352005
Hazard Statement
H315-H319-H335-H373
Target
Carbonic Anhydrase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/mefruside.html
Purity
99.0
Solubility
10 mM in DMSO
Smiles
O=S(C1=CC=C(C(S(=O)(N)=O)=C1)Cl)(N(CC2(OCCC2)C)C)=O
Molecular Formula
C13H19ClN2O5S2
Molecular Weight
382.88
Precautions
P260-P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
[1]Häussinger D, et al. Liver carbonic anhydrase and urea synthesis. Hepatology. 1988 Mar-Apr;8 (2) :435. |[2]Brogden RN, et al. Mefruside: a preliminary report of its pharmacological properties and therapeutic efficacy in oedema and hypertension. Drugs. 1974;7 (6) :419-25.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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