Mefruside

• Description :

  Mefruside is an orally active diuretic and a carbonic anhydrase inhibitor, with a mild hypotensive effect. Mefruside inhibits the synthesis of urea in an isolated rat liver perfusion model. Mefruside can be used in studies of oedema and hypertension[1][2].

• CAS Number :

  [7195-27-9]

• UNSPSC :

  12352005

• Hazard Statement :

  H315-H319-H335-H373

• Target :

  Carbonic Anhydrase

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/mefruside.html

• Purity :

  99.0

• Solubility :

  10 mM in DMSO

• Smiles :

  O=S(C1=CC=C(C(S(=O)(N)=O)=C1)Cl)(N(CC2(OCCC2)C)C)=O

• Molecular Formula :

  C13H19ClN2O5S2

• Molecular Weight :

  382.88

• Precautions :

  P260-P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501

• References & Citations :

  [1]Häussinger D, et al. Liver carbonic anhydrase and urea synthesis. Hepatology. 1988 Mar-Apr;8 (2) :435. |[2]Brogden RN, et al. Mefruside: a preliminary report of its pharmacological properties and therapeutic efficacy in oedema and hypertension. Drugs. 1974;7 (6) :419-25.

• Shipping Conditions :

  Blue Ice

• Storage Conditions :

  -20°C, 3 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported