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Linetastine

CAT: 0804-HY-123103-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-123103-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Linetastine is an orally active and potent 5-Lipoxygenase inhibitor. Linetastine shows antihistamine activity. Linetastine inhibits leukotriene production and antagonizes the effect of histamine. Linetastine inhibits the release of leukotrienes B4 and C4 from calcium ionophore-stimulated human leukocytes[1].
CAS Number
159776-68-8
UNSPSC
12352005
Target
Histamine Receptor; Lipoxygenase
Type
Reference compound
Related Pathways
GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/linetastine.html
Solubility
10 mM in DMSO
Smiles
O=C(/C=C/C=C/C1=CC=C(C(OC)=C1)OC(OCC)=O)NCCN2CCC(CC2)OC(C3=CC=CC=C3)C4=CC=CC=C4
Molecular Formula
C35H40N2O6
Molecular Weight
584.70
References & Citations
[1]Shizawa T, et al. 5-Lipoxygenase inhibitory and antihistamine activities of linetastine. Arzneimittelforschung. 1996 Nov;46 (11) :1072-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
5-LOX; Histamine Receptor

Alternative Products

CatalogName
GTR19198947-01Linetastine

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