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Cefatrizine

CAT: 0804-HY-123024Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-123024Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Cefatrizine (BL-S-640) is an orally active and broad-spectrum cephalosporin antibiotic. Cefatrizine is also a eEF2K inhibitor, with anti-proliferative activity in human breast cancer cells, which could induce ER stress, leading to cell death. Cefatrizine can be used in studies of cancer and bacterial infection[1][2].
CAS Number
51627-14-6
Product Name Alternative
BL-S-640; SK&F 60771
UNSPSC
12352005
Target
Antibiotic; Apoptosis; Bacterial
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/cefatrizine.html
Solubility
H2O : 250 mg/mL (ultrasonic)
Smiles
O=C(O)C(N1[C@@]([H])([C@@H](C1=O)NC([C@@H](C2=CC=C(C=C2)O)N)=O)SC3)=C3CSC4=CNN=N4
Molecular Formula
C18H18N6O5S2
Molecular Weight
462.50
References & Citations
[1]Yao Z, et al. Integrative bioinformatics and proteomics-based discovery of an eEF2K inhibitor (cefatrizine) with ER stress modulation in breast cancer cells. Mol Biosyst. 2016 Mar;12 (3) :729-36. |[2]Leitner F, et al. BL-S640, a cephalosporin with a broad spectrum of antibacterial activity: bioavailability and therapeutic properties in rodents. Antimicrob Agents Chemother. 1975 Mar;7 (3) :306-10.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
β-lactam

Alternative Products

CatalogName
TRC-C237575-50MGCefatrizine
TRC-C237577-50MGCefatrizine-d4
AC39675-01Cefatrizine propylene glycol
269356-01Cefatrizine discontinued. See 163028
sc-504727Cefatrizine 1,2-propanediol
163028Cefatrizine (BL-S-640, S-640P) discontinued

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