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Dehydromiltirone

CAT: 0804-HY-122961-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-122961-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Dehydromiltirone (1,2-Didehydromiltirone) is a diterpenoid quinone with an anti-inflammatory effect. Dehydromiltirone prevents liver injury by modifying the MAPK and NF-κB signaling pathways, reducing neuroinflammatory responses, and inhibiting platelet aggregation. Dehydromiltirone can be used for osteoporosis research[1][2].
CAS Number
116064-77-8
Product Name Alternative
1,2-Didehydromiltirone
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
NF-κB; p38 MAPK
Type
Natural Products
Related Pathways
MAPK/ERK Pathway; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/dehydromiltirone.html
Solubility
10 mM in DMSO
Smiles
O=C1C(C(C)C)=CC2=C(C3=C(C=C2)C(C)(C)CC=C3)C1=O
Molecular Formula
C19H20O2
Molecular Weight
280.36
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Shuqiang Yue, et al. Salvia miltiorrhiza compounds protect the liver from acute injury by regulation of p38 and NFκB signaling in Kupffer cells. Pharm Biol. 2014 Oct;52 (10) :1278-85. |[2]Wei Deng, et al. Dehydromiltirone inhibits osteoclast differentiation in RAW264.7 and bone marrow macrophages by modulating MAPK and NF-κB activity. Front Pharmacol. 2022 Sep 21;13:1015693.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

Alternative Products

CatalogName
TN1562Dehydromiltirone

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