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PHY34

CAT: 0804-HY-122650-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-122650-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PHY34 is an inhibitor that inhibits ATP6V0A2 and CAS thereby inhibiting autophagy, and has a nanomolar effect. PHY34 inhibits cancer cell growth by inducing apoptosis and inhibits tumor growth in xenograft models. PHY34 can be used for research on high grade serous ovarian cancer[1][2].
CAS Number
2130033-55-3
UNSPSC
12352005
Target
Autophagy
Type
Reference compound
Related Pathways
Autophagy
Applications
COVID-19-immunoregulation
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/phy34.html
Purity
98.43
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C2=C(C3=CC=C(OCO4)C4=C3)C5=CC(OC)=C(OC)C=C5C(O[C@H]6[C@@H]([C@]7([H])[C@](OC(C)(O7)C)([H])[C@H](O6)CO)O)=C2CO1
Molecular Formula
C30H30O12
Molecular Weight
582.55
References & Citations
[1]Young AN, et al. Phyllanthusmin Derivatives Induce Apoptosis and Reduce Tumor Burden in High-Grade Serous Ovarian Cancer by Late-Stage Autophagy Inhibition. Mol Cancer Ther. 2018 Oct;17 (10) :2123-2135.|[2]Salvi A, et al. PHY34 inhibits autophagy through V-ATPase V0A2 subunit inhibition and CAS/CSE1L nuclear cargo trafficking in high grade serous ovarian cancer. Cell Death Dis. 2022 Jan 10;13 (1) :45.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
BA3681-1PHY34
A22434-25PHY34 25mg
A22434-500PHY34 500mg
A22434-100PHY34 100mg
A22434-1PHY34 1mg
A22434-50PHY34 50mg
A22434-10PHY34 10mg
A22434-5PHY34 5mg
A22434-2PHY34 2mg

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