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TG693

CAT: 0804-HY-122631-02Size: 10 mM - 1 mLDry Ice: NoHazardous: No
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CAT#:0804-HY-122631-02Size:10 mM - 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TG693 is an orally active inhibitor of CLK1. TG693 regulates the mutated exon 31 of the dystrophin gene in vivo. TG693 is used in Duchenne muscular dystrophy (DMD) research[1].
CAS Number
885272-55-9
UNSPSC
12352005
Hazard Statement
H302
Target
CDK; Dystrophin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/tg693.html
Purity
99.95
Solubility
DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C12=C(NN=C2)C=CC(C3=CC=NC=C3)=C1
Molecular Formula
C12H9N3
Molecular Weight
195.22
Precautions
H302
References & Citations
[1]Sako Y, et al. Development of an orally available inhibitor of CLK1 for skipping a mutated dystrophin exon in Duchenne muscular dystrophy. Sci Rep. 2017 May 30;7:46126.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

5-(Pyridin-4-yl)-1H-indazole
CAS Number885272-55-9
PubChem CID53399664
IUPAC Name5-pyridin-4-yl-1H-indazole
Molecular FormulaC12H9N3
Molecular Weight195.22
XLogP2.1
Topological Polar Surface Area41.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Heavy Atom Count15
Formal Charge0
Complexity213
SMILES
C1=CC2=C(C=C1C3=CC=NC=C3)C=NN2
InChI
InChI=1S/C12H9N3/c1-2-12-11(8-14-15-12)7-10(1)9-3-5-13-6-4-9/h1-8H,(H,14,15)
InChIKey
CILGVAIRQUNMLT-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 5-(Pyridin-4-yl)-1H-indazole
CAS: 885272-55-9
CID: 53399664
Formula: C12H9N3
MW: 195.22
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight195.22
XLogP32.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count1
Exact Mass195.079647300
Monoisotopic Mass195.079647300
Topological Polar Surface Area41.6 Ų
Heavy Atom Count15
Formal Charge0
Complexity213
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
M16408TG693

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