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Pyrazofurin

CAT: 0804-HY-122502-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-122502-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Pyrazofurin is an antitumor pyrimidine nucleoside analogue and a orotate-phosphoribosyltransferase inhibitor. Pyrazofurin inhibits cell proliferation and intracellular DNA synthesis by inhibiting uridine 5'-phosphate synthase. Pyrazofurin is also an antibiotic with a broad spectrum of antiviral activity[1][2][3][4].
CAS Number
30868-30-5
Product Name Alternative
Pirazofurin
UNSPSC
12352005
Target
Antibiotic; DNA/RNA Synthesis; HIV; Influenza Virus; SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/pyrazofurin.html
Purity
98.18
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : 5 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(N)C1=NNC([C@@H]2O[C@@H]([C@H]([C@H]2O)O)CO)=C1O
Molecular Formula
C9H13N3O6
Molecular Weight
259.22
References & Citations
[1]Ringer DP, et al. Alteration in de novo pyrimidine biosynthesis during uridine reversal of pyrazofurin-inhibited DNA synthesis. Neuropsychopharmacology. J Biochem Toxicol. 1991 Spring;6 (1) :19-27.|[2]Peters GJ, et al. Antipyrimidine effects of five different pyrimidine de novo synthesis inhibitors in three head and neck cancer cell lines. Nucleosides Nucleotides Nucleic Acids. 2018;37 (6) :329-339.|[3]Petrie CR 3rd, et al. Synthesis and biological activity of certain nucleoside and nucleotide derivatives of pyrazofurin. J Med Chem. 1986 Feb;29 (2) :268-78. |[4]Canonico PG, et al. Antiviral efficacy of pyrazofurin against selected RNA viruses. Antiviral Res. 1982 Dec;2 (6) :331-7.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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