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Desethylamiodarone

CAT: 0804-HY-122423Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-122423Size:1 Each
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Description
Desethylamiodarone (N-Deethylamiodarone) is the major metabolite of antiarrhythmic compound Amiodarone. Desethylamiodarone has antiarrhythmic activity. Desethylamiodaron also induces cancer cell apoptosis[1][2].
CAS Number
83409-32-9
Product Name Alternative
N-Deethylamiodarone; LB 33020
UNSPSC
12352005
Target
Apoptosis; Drug Metabolite
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/desethylamiodarone.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC(I)=C(C(I)=C1)OCCNCC)C2=C(OC3=CC=CC=C23)CCCC
Molecular Formula
C23H25I2NO3
Molecular Weight
617.26
References & Citations
[1]Bognar Z, et al. Desethylamiodarone-A metabolite of amiodarone-Induces apoptosis on T24 human bladder cancer cells via multiple pathways. PLoS One. 2017 Dec 8;12 (12) :e0189470.|[2]Kannan R, et al. Amiodarone toxicity. II. Desethylamiodarone-induced phospholipidosis and ultrastructural changes during repeated administration in rats. Fundam Appl Toxicol. 1991 Jan;16 (1) :103-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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