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ACG548B

CAT: 0804-HY-122140-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-122140-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ACG548B (compound 24) is a potent inhibitor of acetyl- and butyrylcholinesterase (AChE and BChE) with IC50s of 1.78 and 0.496 μM, respectively. ACG548B has higher AChE affinity and selectivity over BChE and ChoK (choline kinase) . ACG548B can be uesd for the study of myasthenia gravis and neuromuscular blockade[1].
CAS Number
795316-16-4
UNSPSC
12352005
Target
Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/acg548b.html
Purity
99.72
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CN(C1=CC=[N+](CC2=CC(C3=CC=CC(C[N+]4=CC=C(N(C5=CC=C(Cl)C=C5)C)C=C4)=C3)=CC=C2)C=C1)C6=CC=C(Cl)C=C6.[Br-].[Br-]
Molecular Formula
C38H34Br2Cl2N4
Molecular Weight
777.42
References & Citations
[1]Conejo-García A, et al. Homodimeric bis-quaternary heterocyclic ammonium salts as potent acetyl- and butyrylcholinesterase inhibitors: a systematic investigation of the influence of linker and cationic heads over affinity and selectivity. J Med Chem. 2011;54 (8) :2627-2645.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE

Alternative Products

CatalogName
MBS5801061ACG548B

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