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Memoquin

CAT: 0804-HY-122080Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-122080Size:1 Each
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Description
Memoquin is an anti-amyloid and anti-oxidant multi-target-directed ligand. Memoquin is an orally active inhibitor of BACE-1 and AChE with IC50 values of 108 and 1.55 nM, respectively. Memoquin is a cognitive enhancer that prevents the Aβ-induced neurotoxicity mediated by oxidative stress. Memoquin can be used for the research of Alzheimer’s disease (AD) [1][2].
CAS Number
616885-87-1
UNSPSC
12352005
Target
Amyloid-β; Beta-secretase; Cholinesterase (ChE)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/memoquin.html
Solubility
10 mM in DMSO
Smiles
O=C1C(NCCCCCCN(CC2=CC=CC=C2OC)CC)=CC(C(NCCCCCCN(CC3=CC=CC=C3OC)CC)=C1)=O
Molecular Formula
C38H56N4O4
Molecular Weight
632.88
References & Citations
[1]Capurro V, et al. Pharmacological characterization of memoquin, a multi-target compound for the treatment of Alzheimer's disease. PLoS One. 2013;8 (2) :e56870.|[2]Cavalli A, et al. A small molecule targeting the multifactorial nature of Alzheimer's disease. Angew Chem Int Ed Engl. 2007;46 (20) :3689-92.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BACE1

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