(Z) -KC02

CAT: 0804-HY-121892Size: 1 mg (34.80 mM x 100 μL in Ethyl Acetate)Dry Ice: NoHazardous: No
CAT#:0804-HY-121892Size:1 mg (34.80 mM x 100 μL in Ethyl Acetate)
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Description
(Z) -KC02 is an inhibitor of ABHD16A, the phosphatidylserine (PS) lipase that produces lyso-PS. Lysophosphatidylserine (lyso-PS) is a signaling lipid that regulates immune and neurological processes. It is associated with several neurological disorders such as retinitis pigmentosa and cataracts (PHARC) . (Z) -KC02 depletes lyso-PS in lymphoblasts from PHARC subjects. (Z) -KC02 also reduces lyso-PS and lipopolysaccharide-induced cytokine production in macrophages and modulates lyso-PS metabolism in vivo[1].
CAS Number
[1646795-60-9]
UNSPSC
12352005
Target
TNF Receptor
Type
Reference compound
Related Pathways
Apoptosis
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/z-kc02.html
Concentration
34.80 mM * 100 μL in Ethyl acetate
Purity
99.0
Solubility
10 mM in DMSO
Smiles
O=C(N)CCCC/C=C1C(OC\1CCC2=CC=CC=C2)=O
Molecular Formula
C17H21NO3
Molecular Weight
287.35
References & Citations
[1]Kamat SS, Camara K, Parsons WH, Chen DH, Dix MM, Bird TD, Howell AR, Cravatt BF. Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay. Nat Chem Biol. 2015 Feb;11 (2) :164-71.
Shipping Conditions
Blue Ice
Storage Conditions
Solution, -20°C, 2 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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