Epiyangambin

CAT: 0804-HY-121377Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-121377Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Epiyangambin is a competitive platelet activating factor receptor (PAF) antagonist that dose-dependently inhibits PAF-induced platelet aggregation. Epiyangambin also inhibits the growth of human colon cancer cells (SW480 cells) [1][2].

CAS Number

24192-64-1

UNSPSC

12352005

Hazard Statement

H315-H319-H335

Target

Platelet-activating Factor Receptor (PAFR)

Type

Natural Products

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/epiyangambin.html

Solubility

10 mM in DMSO

Smiles

COC1=C(OC)C(OC)=CC([C@H]2OC[C@]3([H])[C@H](C4=CC(OC)=C(OC)C(OC)=C4)OC[C@@]32[H])=C1

Molecular Formula

C24H30O8

Molecular Weight

446.49

Precautions

P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

References & Citations

[1]Hausott B, et al. Naturally occurring lignans efficiently induce apoptosis in colorectal tumor cells. J Cancer Res Clin Oncol. 2003 Oct;129 (10) :569-76.|[2]Castro-Faria-Neto HC, et al. Pharmacological profile of epiyangambin: a furofuran lignan with PAF antagonist activity. J Lipid Mediat. 1993 May;7 (1) :1-9.

Shipping Conditions

Room temperature

Scientific Category

Natural Products

Clinical Information

No Development Reported

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