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Carumonam

CAT: 0804-HY-121329Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-121329Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Carumonam (AMA-1080; Ro 17-2301) is a sulfonated monocyclic β-Lactam Antibiotic, targeting to penicillin-binding protein (PBP) . Carumonam exerts highly activity against Enterobacteriaceae, Pseudomonas aeruginosa, and Haemophilus influenzae, while it weakly and even inactively inhibits Streptococcus pneumoniae and Staphylococcus aureus. Carumonam is resistant to beta-lactamase-mediated hydrolysis[1].
CAS Number
87638-04-8
Product Name Alternative
AMA-1080; Ro 17-2301
UNSPSC
12352005
Target
Antibiotic; Bacterial; Penicillin-binding protein (PBP)
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/carumonam.html
Solubility
10 mM in DMSO
Smiles
O=C(CO/N=C(C(N[C@H]1[C@H](N(C1=O)S(=O)(O)=O)COC(N)=O)=O)/C2=CSC(N)=N2)O
Molecular Formula
C12H14N6O10S2
Molecular Weight
466.40
References & Citations
[1]Imada A, et al. In vitro and in vivo antibacterial activities of carumonam (AMA-1080), a new N-sulfonated monocyclic beta-lactam antibiotic. Antimicrob Agents Chemother. 1985 May;27 (5) :821-7. |[2]Kita Y, et al. Comparative pharmacokinetics of carumonam and aztreonam in mice, rats, rabbits, dogs, and cynomolgus monkeys. Antimicrob Agents Chemother. 1986 Jan;29 (1) :127-34.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
β-lactam

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