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Balanol

CAT: 0804-HY-121197Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-121197Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Balanol (Ophiocordin; Azepinostatin) is a potent and ATP competitive PKC/PKA inhibitor against human PKC isozymes α, β-I, β-II, γ, δ, ε, η (IC50s=4-9 nM) and ζ (IC50=150 nM) . Balanol also blocks the phosphorylation of cyclic AMP response element-binding protein (CREB) and myristoylated alanine-rich C kinase substrate (MARCKS) . Balanol can be isolated from the fungus Verticillium balanoides[1][2].
CAS Number
63590-19-2
Product Name Alternative
Ophiocordin; Azepinostatin
UNSPSC
12352005
Target
MARCKS; PKA; PKC
Type
Natural Products
Related Pathways
Cytoskeleton; Epigenetics; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/balanol.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(C=C(C(O[C@H]2[C@@H](CNCCC2)NC(C3=CC=C(O)C=C3)=O)=O)C=C1O)O)C4=C(C=CC=C4O)C(O)=O
Molecular Formula
C28H26N2O10
Molecular Weight
550.51
References & Citations
[1]Gustafsson AB, et al. Differential and selective inhibition of protein kinase A and protein kinase C in intact cells by balanol congeners. Mol Pharmacol. 1999 Aug;56 (2) :377-82. |[2]Kulanthaivel P, et al. Balanol: a novel and potent inhibitor of protein kinase C from the fungus Verticillium balanoides. Journal of the American Chemical Society, 1993, 115 (14) : 6452-6453.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
PKA; PKCα; PKCβ; PKCγ; PKCδ; PKCε; PKCη

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