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L-NIL (hydrochloride)

CAT: 0804-HY-12117Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-12117Size:1 Each
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Description
L-NIL hydrochloride is an inducible NO synthase inhibitor, with an IC50 of 3.3 μM for mouse inducible NOS[1][2][3].
CAS Number
150403-89-7
UNSPSC
12352211
Hazard Statement
H315-H319-H335
Target
NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/l-nil-hydrochloride.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
OC([C@@H](N)CCCCNC(C)=N)=O.Cl
Molecular Formula
C8H18ClN3O2
Molecular Weight
223.70
Precautions
P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362+P364-P403+P233-P405-P501
References & Citations
[1]Consuelo Pasten, et al. l-NIL prevents the ischemia and reperfusion injury involving TLR-4, GST, clusterin, and NFAT-5 in mice. Am J Physiol Renal Physiol. 2019 Apr 1;316 (4) :F624-F634.|[2]Sharon Angela Tanuseputero, et al. Intravenous Arginine Administration Downregulates NLRP3 Inflammasome Activity and Attenuates Acute Kidney Injury in Mice with Polymicrobial Sepsis. Mediators Inflamm. 2020 May 11;2020:3201635.|[3]Moore WM, et al. L-N6- (1-iminoethyl) lysine: a selective inhibitor of inducible nitric oxide synthase. J Med Chem. 1994 Nov 11;37 (23) :3886-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

N6-(1-Iminoethyl)-L-lysine hydrochloride (1:2)

See also: L-N6-(1-Iminoethyl)lysine hydrochloride (annotation moved to).

CAS Number150403-89-7
PubChem CID9794509
IUPAC Name(2S)-2-amino-6-(1-aminoethylideneamino)hexanoic acid;hydrochloride
Molecular FormulaC8H18ClN3O2
Molecular Weight223.70
Topological Polar Surface Area102
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Heavy Atom Count14
Formal Charge0
Complexity192
SMILES
CC(=NCCCC[C@@H](C(=O)O)N)N.Cl
InChI
InChI=1S/C8H17N3O2.ClH/c1-6(9)11-5-3-2-4-7(10)8(12)13;/h7H,2-5,10H2,1H3,(H2,9,11)(H,12,13);1H/t7-;/m0./s1
InChIKey
HJYWSATZDBEAOS-FJXQXJEOSA-N
Chemical Structure
2D Structure
2D structure of N6-(1-Iminoethyl)-L-lysine hydrochloride (1:2)
CAS: 150403-89-7
CID: 9794509
Formula: C8H18ClN3O2
MW: 223.70
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight223.70
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass223.1087545
Monoisotopic Mass223.1087545
Topological Polar Surface Area102 Ų
Heavy Atom Count14
Formal Charge0
Complexity192
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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