Products for Research Use Only
RegisterLogin

AZ1729

CAT: 0804-HY-121140Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-121140Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
AZ1729 is a potent free fatty acid 2 receptor (FFA2) activator, acting as a direct allosteric agonist and as a positive allosteric modulator. AZ1729 increases the activity of the endogenously produced short chain fatty acid propionate in Gi-mediated pathways, but not at those transduced by Gq/G11. AZ1729 induces inhibition of isoproterenol-induced lipolysis in mouse adipocytes. AZ1729 also can Induce migration of human neutrophils. AZ1729 can be used for researching the signaling pathways of the physiological roles of FFA2[1].
CAS Number
2016864-46-1
UNSPSC
12352005
Target
Free Fatty Acid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/az1729.html
Purity
99.8
Solubility
10 mM in DMSO
Smiles
O=C(NC1=CC=CC(C2=C(C)N=C(NC(N)=N)S2)=C1)C3=CC=C(F)C=C3
Molecular Formula
C18H16FN5OS
Molecular Weight
369.42
References & Citations
[1]Bolognini D, Moss CE, Nilsson K, et al. A Novel Allosteric Activator of Free Fatty Acid 2 Receptor Displays Unique Gi-functional Bias. J Biol Chem. 2016;291 (36) :18915-18931.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-160107AZ1422

Alternative Products

CatalogName
BA5335-5AZ1729

Popular Products