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Funalenone

CAT: 0804-HY-121096Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-121096Size:1 mg
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Description
Funalenone (BMS-304245) is a MraY + MurG inhibitor with an IC50 of 25.5 μM in a MraY + MurG membrane plate assay. Funalenone inhibits Staphylococcus aureus (A15090) with an MIC of 64 μg/mL. Funalenone also inhibits MMP-1 with an IC50 of 170 μM[1][2].
CAS Number
259728-61-5
Product Name Alternative
BMS-304245
UNSPSC
12352005
Hazard Statement
H302+H312+H332
Target
Bacterial; HIV Integrase; MMP
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/funalenone.html
Solubility
10 mM in DMSO
Smiles
O=C1C(OC)=C(O)C2=C3C1=C(O)C=C(O)C3=C(C)C=C2O
Molecular Formula
C15H12O6
Molecular Weight
288.25
Precautions
H302+H312+H332
References & Citations
[1]J Inokoshi, et al. Funalenone, a novel collagenase inhibitor produced by Aspergillus niger. J Antibiot (Tokyo) . 1999 Dec;52 (12) :1095-100. |[2]Kazuro Shiomi, et al. Fungal phenalenones inhibit HIV-1 integrase. J Antibiot (Tokyo) . 2005 Jan;58 (1) :65-8. |[3]Zawadzke LE, et al. Targeting the MraY and MurG bacterial enzymes for antimicrobial therapeutic intervention. Anal Biochem. 2003 Mar 15;314 (2) :243-52.|[4]Inokoshi J, et al. Funalenone, a novel collagenase inhibitor produced by Aspergillus niger. J Antibiot (Tokyo) . 1999 Dec;52 (12) :1095-100.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MMP-1

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sc-364493AFunalenone
207194Funalenone (3,4,7,9-Tetrahydroxy-6-methyl-1H-phenalen-1-one)

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