Palmostatin B

CAT: 0804-HY-120911Size: InquireDry Ice: NoHazardous: No
CAT#:0804-HY-120911Size:Inquire
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CAS Number
[1233365-12-2]
UNSPSC Description
Palmostatin B is an Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitor. Palmostatin B reduces cell viability in a panel of NRAS mutant melanoma cell lines. Palmostatin B inhibits Ras depalmitoylation in cells[1][2].
Target Antigen
Phospholipase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/palmostatin-b.html
Solubility
10 mM in DMSO
Smiles
O=C1O[C@@H](CCC2=CC=C(OC)C(OC)=C2)[C@@H]1CCCCCCCCCC
Molecular Weight
376.53
References & Citations
[1]Vujic I, et al. Acyl protein thioesterase 1 and 2 (APT-1, APT-2) inhibitors palmostatin B, ML348 and ML349 have different effects on NRAS mutant melanoma cells. Oncotarget. 2016 Feb 9;7(6):7297-306.|[2]Dekker FJ, et al. Small-molecule inhibition of APT1 affects Ras localization and signaling. Nat Chem Biol. 2010 Jun;6(6):449-56.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported

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