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Navafenterol

CAT: 0804-HY-120802Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-120802Size:1 Each
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Description
Navafenterol (AZD-8871) is an inhaled dual-acting, potent, selective, and long-lasting M3-antagonist/β2-agonist (MABA) with long-lasting effects and favorable safety profile. The pIC50 is 9.5 for human M3 receptor, and the pEC50 is 9.5 for β2-adrenoceptor. Navafenterol can be used for the research of chronic obstructive pulmonary disease (COPD) . Bronchoprotective and antisialagogue effects. Favorable cardiovascular profile[1].
CAS Number
1435519-06-4
Product Name Alternative
AZD-8871; LAS191351
UNSPSC
12352005
Target
Adrenergic Receptor; mAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/navafenterol.html
Solubility
10 mM in DMSO
Smiles
O=C(C(O)(C1=CC=CS1)C2=CC=CS2)O[C@H]3CC[C@@H](CC3)N(C)CCCN4N=NC5=CC(CNC[C@H](O)C6=CC=C(C7=C6C=CC(N7)=O)O)=CC=C54
Molecular Formula
C38H42N6O6S2
Molecular Weight
742.91
References & Citations
[1]Mònica Aparici, et al. Pharmacological Profile of AZD8871 (LAS191351), a Novel Inhaled Dual M3 Receptor Antagonist/ β 2-Adrenoceptor Agonist Molecule with Long-Lasting Effects and Favorable Safety Profile. J Pharmacol Exp Ther. 2019 Jul;370 (1) :127-136.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
MAChR3

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