NCDM-32B

• Description :

  NCDM-32B is a potent and selective KDM4 inhibitor, with IC50 values of 3.0 μM for KDM4A and 1.0 μM for KDM4C in in vitro enzyme assays. NCDM-32B specifically increases global H3K9me3/me2 levels in basal breast cancer cells. NCDM-32B impairs the viability of KDM4C-amplified basal breast cancer cell lines (HCC1954 and Colo824) . NCDM-32B can be used for the study of breast cancer[1][2].

• UNSPSC :

  12352211

• Hazard Statement :

  H302, H315, H319, H335

• Target :

  Histone Demethylase

• Type :

  Reference compound

• Related Pathways :

  Epigenetics

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ncdm-32b.html

• Purity :

  97.0

• Solubility :

  Ethanol : 25 mg/mL (ultrasonic; warming)

• Smiles :

  O=C(CCN(O)C(CCCCCCCCN(C)C)=O)OC

• Molecular Formula :

  C15H30N2O4

• Molecular Weight :

  302.41

• Precautions :

  H302, H315, H319, H335

• References & Citations :

  [1]Ye Q, et al. Genetic alterations of KDM4 subfamily and therapeutic effect of novel demethylase inhibitor in breast cancer. Am J Cancer Res. 2015 Mar 15;5 (4) :1519-30.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  KDM4

• CAS Number :

  [1239468-48-4]