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Reticulol

CAT: 0804-HY-120241Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-120241Size:1 Each
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Description
Reticulol (K 251-1) is an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. Reticulol shows antitumor activity independent with cell cycle arrest or apoptosis. Reticulol inhibits cell growth of murine melanoma cells and human lung tumor cells. Reticulol protects its lung metastasis via the bloodstream by inhibiting the growth of B16F10 melanoma[1][2].
CAS Number
26246-41-3
Product Name Alternative
K 251-1
UNSPSC
12352005
Hazard Statement
H302+H312-H319
Target
Phosphodiesterase (PDE)
Type
Natural Products
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/reticulol.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(O)C(OC)=C(O)C=C2C=C(C)O1
Molecular Formula
C11H10O5
Molecular Weight
222.19
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Furutani Y, et al. Reticulol, an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. J Antibiot (Tokyo) . 1975 Jul;28 (7) :558-60. |[2]Lim DS, et al. Antitumor efficacy of reticulol from Streptoverticillium against the lung metastasis model B16F10 melanoma. Lung metastasis inhibition by growth inhibition of melanoma. Chemotherapy. 2003 Jun;49 (3) :146-53. |[3]Furutani Y, et al. Reticulol, an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. J Antibiot (Tokyo) . 1975 Jul;28 (7) :558-60.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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