Products for Research Use Only
RegisterLogin

DD1

CAT: 0804-HY-120035-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-120035-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
DD1, a proteasome inhibitor, targets Bax activation and P70S6K degradation during acute myeloid leukemia (AML) apoptosis. DD1 induces apoptosis in the caspase-dependent manner. DD1 induces mitochondrial membrane depolarization and Bad dephosphorylation[1].
CAS Number
187585-11-1
UNSPSC
12352005
Hazard Statement
H301
Target
Apoptosis; Proteasome; Ribosomal S6 Kinase (RSK)
Type
Reference compound
Related Pathways
Apoptosis; MAPK/ERK Pathway; Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dd1.html
Purity
99.40
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1C(N)=C(C2=CC=C(OC)C(N)=C2)OC3=CC=CC=C13
Molecular Formula
C16H14N2O3
Molecular Weight
282.29
Precautions
H301
References & Citations
[1]Marion Piedfer, et al. p70S6 kinase is a target of the novel proteasome inhibitor 3,3'-diamino-4'-methoxyflavone during apoptosis in human myeloid tumor cells. Biochim Biophys Acta. 2013 Jun;1833 (6) :1316-28.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P70S6K

Alternative Products

CatalogName
CN-A038-500GMAgar, Micropropagation - Type I (Gracilaria)
M2302-20HPhaseShield™ Gel Tubes, Heavy (200x 2ml)
M2302-20LPhaseShield™ Gel Tubes, Light (200x 2ml)
BCS81BioCoupler® Glass Set (8 oz) x1
RHD55901Anti-PTGS1 Antibody (R1S27)
RHD55804Anti-TCEA1 Antibody (R1S24)
E-KAB-0614Porcine IL-2 Antibody Pair Set
RHD55803Anti-TCEA1 Antibody (R1S23)
PKSH030904Recombinant Human Purine nucleoside phosphorylase/PNP Protein (His Tag)
PKSH031350Recombinant Human Ficolin-1/Ficolin-A/FCN1 Protein (His Tag)

Popular Products