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AR03

CAT: 0804-HY-119993-03Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-119993-03Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AR03 (BMH-23) is an apurinic/apyrimidinic endonuclease 1 (Ape1) inhibitor with an IC50 of 2.1 µM. AR03 has low affinity for double-stranded DNA. AR03 potentiates the cytotoxicity of methyl methanesulfonate and temozolomide in SF767 cells[1].
CAS Number
510721-85-4
Product Name Alternative
BMH-23
UNSPSC
12352005
Target
DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ar03.html
Purity
99.1
Solubility
10 mM in DMSO
Smiles
CC1=C2N=C3N=C(C=C(C3=C(C2=CC=C1)N)C)C
Molecular Formula
C15H15N3
Molecular Weight
237.30
References & Citations
[1]Aditi Bapat, et al. Novel small-molecule inhibitor of apurinic/apyrimidinic endonuclease 1 blocks proliferation and reduces viability of glioblastoma cells. J Pharmacol Exp Ther. 2010 Sep 1;334 (3) :988-98.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

2,4,9-Trimethylbenzo(b)(1,8)naphthyridin-5-amine

structure in first source in first source

CAS Number510721-85-4
PubChem CID698490
IUPAC Name2,4,9-trimethylbenzo[b][1,8]naphthyridin-5-amine
Molecular FormulaC15H15N3
Molecular Weight237.30
XLogP3.2
Topological Polar Surface Area51.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Heavy Atom Count18
Formal Charge0
Complexity306
SMILES
CC1=C2C(=CC=C1)C(=C3C(=CC(=NC3=N2)C)C)N
InChI
InChI=1S/C15H15N3/c1-8-5-4-6-11-13(16)12-9(2)7-10(3)17-15(12)18-14(8)11/h4-7H,1-3H3,(H2,16,17,18)
InChIKey
WRUVTYDQVPMYDZ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2,4,9-Trimethylbenzo(b)(1,8)naphthyridin-5-amine
CAS: 510721-85-4
CID: 698490
Formula: C15H15N3
MW: 237.30
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight237.30
XLogP33.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count0
Exact Mass237.126597491
Monoisotopic Mass237.126597491
Topological Polar Surface Area51.8 Ų
Heavy Atom Count18
Formal Charge0
Complexity306
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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