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Melarsoprol

CAT: 0804-HY-119594-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-119594-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Melarsoprol, a melaminophenylarsine-type trivalent organic arsenical, is an important agent for African trypanosomiasis. Melarsoprol inhibits the growth of lymphoid leukemic cell by inducing apoptosis. Melarsoprol crosses the blood-brain barrier[1][2][3].
CAS Number
494-79-1
UNSPSC
12352005
Hazard Statement
H301+H331, H410
Target
Apoptosis; Parasite
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Infection; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/melarsoprol.html
Purity
98.0
Solubility
DMSO : 36 mg/mL (ultrasonic; warming)
Smiles
OCC1S[As](SC1)C2=CC=C(C=C2)NC3=NC(N)=NC(N)=N3
Molecular Formula
C12H15AsN6OS2
Molecular Weight
398.34
Precautions
H301+H331, H410
References & Citations
[1]Z Gregus, et al. Role of glutathione in the biliary excretion of the arsenical drugs trimelarsan and melarsoprol. Biochem Pharmacol. 2000 Jun 1;59 (11) :1375-85.|[2]König A, et al. Comparative activity of melarsoprol and arsenic trioxide in chronic B-cell leukemia lines. Blood. 1997 Jul 15;90 (2) :562-70. |[3]Ben Zirar S, et al. Comparison of nanosuspensions and hydroxypropyl-beta-cyclodextrin complex of melarsoprol: pharmacokinetics and tissue distribution in mice. Eur J Pharm Biopharm. 2008 Oct;70 (2) :649-56.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched

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