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Acetylaszonalenin

CAT: 0804-HY-119552Size: 500 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-119552Size:500 µg
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Description
Acetylaszonalenin, a prenylated indole derivative, is a fungal metabolite.Acetylaszonalenin is a potent neurokinin-1 (NK1) receptor antagonist. Acetylaszonalenin shows inhibition of [3H]-SP binding to human astrocytoma cells with a Ki of 170 μM[1][2].
CAS Number
42230-55-7
Product Name Alternative
LL-S490β
UNSPSC
12352005
Target
Endogenous Metabolite; Neurokinin Receptor
Type
Natural Products
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/acetylaszonalenin.html
Solubility
10 mM in DMSO
Smiles
O=C1N2[C@@]([H])(C(NC3=CC=CC=C13)=O)C[C@]4([C@@]2(N(C5=C4C=CC=C5)C(C)=O)[H])C(C)(C=C)C
Molecular Formula
C25H25N3O3
Molecular Weight
415.48
References & Citations
[1]Wen-Bing Yin, et al. Acetylaszonalenin biosynthesis in Neosartorya fischeri. Identification of the biosynthetic gene cluster by genomic mining and functional proof of the genes by biochemical investigation. J Biol Chem. 2009 Jan 2;284 (1) :100-109.|[2]C J Barrow, et al. Spiroquinazoline, a novel substance P inhibitor with a new carbon skeleton, isolated from Aspergillus flavipes. J Nat Prod. 1994 Apr;57 (4) :471-6.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
Microbial Metabolite; NK1R

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CatalogName
MBS5814338Acetylaszonalenin

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