GSK466317A

CAT: 0804-HY-119232Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-119232Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

GSK466317A is a PKA inhibitor, with an IC50 of 12.59 μM. GSK466317A also inhibits GRK1, GRK2, and GRK5, with IC50s of 1000, 31.62, and 39.81 μM, respectively[1].

CAS Number

864082-48-4

UNSPSC

12352005

Target

G Protein-coupled Receptor Kinase (GRK) ; PKA

Type

Reference compound

Related Pathways

GPCR/G Protein; Stem Cell/Wnt; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gsk466317a.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CC2=C(C(Cl)=C1)NN=C2)C3=C(NC(CC3C4=CC=C(C=C4)C(F)(F)F)=O)C

Molecular Formula

C21H16ClF3N4O2

Molecular Weight

448.83

References & Citations

[1]Homan KT, et, al. Identification and structure-function analysis of subfamily selective G protein-coupled receptor kinase inhibitors. ACS Chem Biol. 2015 Jan 16;10 (1) :310-9.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

GRK2; PKA

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T27479-01	GSK466317A

GSK466317A

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